Protein Details: Voltage-gated sodium channel subunit alpha Nav1.4
Protein ID
ICDB_Pro_0881
Protein Name
Voltage-gated sodium channel subunit alpha Nav1.4
Gene Name
SCN4A
Organism
Equus caballus (Horse)
Length
1834 amino acids
AlphaFoldDB
AF-Q28371-F1-model_v4.pdb
Function
Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting; activated and inactivated states (By similarity). Required for normal muscle fiber excitability; normal muscle contraction and relaxation cycles; and constant muscle strength in the presence of fluctuating K(+) levels .
Sequence
MASSSLPNLVPLGPESLRPFTRASLAAIERRALEEEARLQRNKQMEIQETERNARSDLEAGKNLPLIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYMLSPFSIIRRSAIKVLIHSLFSMFIMITILPNCVVMTMSDPPPWPIHVENTFTGINTFESLIKMLARGFCIDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPQPFNDTNTTWYGNDTWYSNDTWNSNDTWSSNDMWNSHESMASNYTFDWDAYINDEGNFYFLEGAKDALLCGNSSDAGHCPEGYKCIKTGRNPNYGYTSHDTFSWAFLALFRLMIQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVTMAYAEQNEATLAEDQEKEEEFQQMMEKFQKQQEELEKAKADQALEGGEAGGDPAHSKDCNGSLDTSPGEKGPPRQSCSADSGVSDAMEELEEAHQKCPPWWYKCAHKVLIWNCCTPWVKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDKVLTVGNLVFTGIFTAEMVLKLIALDPYEYFQQGWNVFDSIIVTLSWVELGLVNVKGLSVLRSFRLVRSLKLAKSWPTLNMFIRIIGNSGGGLGNLTLVLAIIVVNFSVVGMQLFGKNYKECVCKNASDCALPRWKMCDFFHSFLIVLRILCGEWIEPMWGFMEVAGQAMFLTVLLMVMVNGNLVDLDLFLALLLNPLNSDNLSASDEDGEMNNLQISSWPIKLGICFANAFLLGLLHGKILSPKDIMLSLGDPGEAGEAGEAEESAPEDEKKEPPPEDDDKDLKKDNHILNHMGLVDGTPTSIELDHLNFINNPYLTIHVPIASEESDLEMPTEEETDTFSEPEDGKKPLQPLDGNSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRFPCLSVDISQGRGKMWWTLRRACFKIVEHHWFKTFNSSLILLNSGTLAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWVIFSIMGVNLFAAKIYYFINTTTSERFDISGVNNKSECESLIHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYSAVDSREQEEQPQYEVNIYMYLYFVIFIIFGSFFTINSLIRLIIVNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDFVTKQVFDITIMILICLNMVTMMVETDDQSQLKVDILYNINMVFIIVFTGECVLKMFALRQNYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLILVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPTLENPGTSVRGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSDPLGEDDFEIFFEKWEKFGPDATQFIDYSRLSDFVDTLQEPLRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKETMEEKFMAANPSKVSYEPITTTLKRKQEEVCAIKIQRAYRRHLLQRSVKQASYMYRHSQDGSGDGAPEKEGLIANTMSKMYGRENGNSGVQNKGEERGSTGDAGPTMGLTPINPSDSALPPSPPPGLPLHPGVKESLV
PDB Structures
Ligand Binding
Binding Site
401
Disease
Location
Required for normal muscle fiber excitability; normal muscle contraction and relaxation cycles; and constant muscle strength in the presence of fluctuating K+ levels
DOI ID
10.1038/ng1092-144
RefSeq
NP_001075230.1